STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ncx-2Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (975 aa)    
Predicted Functional Partners:
ncx-9
Mitochondrial sodium/calcium exchanger protein; Mitochondrial sodium/calcium antiporter that mediates sodium- dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis (Probable). Required for patterning of neural circuits: functions in the same pathway as RAC- dependent effectors of the unc-6/netrin signaling pathway to set left/ right patterning of the VD/DD GABAergic circuit. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
      
 0.871
ncx-10
Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
      
 0.869
ncx-6
Putative sodium/calcium exchanger 6.
      
 0.868
ncx-8
Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
   
  
 0.831
ncx-1
Sodium-calcium exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
  
 
0.831
ncx-7
Putative sodium/calcium exchanger 7.
      
 0.730
cbd-1
Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization.
    
 
 0.558
ncx-4
Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
   
  
0.502
ncx-5
Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
   
  
0.479
myo-3
Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
  
 0.467
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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