node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alg-1 | alg-2 | F48F7.1b.1 | T07D3.7a.1 | Protein argonaute; Belongs to the argonaute family. | Protein argonaute; Belongs to the argonaute family. | 0.941 |
alg-1 | cgh-1 | F48F7.1b.1 | C07H6.5.1 | Protein argonaute; Belongs to the argonaute family. | ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.864 |
alg-1 | ergo-1 | F48F7.1b.1 | R09A1.1a.1 | Protein argonaute; Belongs to the argonaute family. | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] | 0.927 |
alg-1 | hbl-1 | F48F7.1b.1 | F13D11.2a.1 | Protein argonaute; Belongs to the argonaute family. | Hunchback-like protein; Required for the late stages of development. Plays a role in the developmental timing of postembryonic hypodermal seam cell fusion events and adult alae production. | 0.724 |
alg-1 | lin-14 | F48F7.1b.1 | T25C12.1a.1 | Protein argonaute; Belongs to the argonaute family. | Protein lin-14; Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of insulin/insulin- like growth factor gene ins-33. Isoform A may be involved in specifying L1 cell fates while isoform B1 and isoform B2 may specify L2 and later cell fates, creating a temporal switch. | 0.703 |
alg-1 | lin-28 | F48F7.1b.1 | F02E9.2a.1 | Protein argonaute; Belongs to the argonaute family. | Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family. | 0.690 |
alg-1 | lin-29 | F48F7.1b.1 | W03C9.4a.1 | Protein argonaute; Belongs to the argonaute family. | Transcription factor. | 0.494 |
alg-1 | lin-41 | F48F7.1b.1 | C12C8.3a.1 | Protein argonaute; Belongs to the argonaute family. | Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] | 0.987 |
alg-2 | alg-1 | T07D3.7a.1 | F48F7.1b.1 | Protein argonaute; Belongs to the argonaute family. | Protein argonaute; Belongs to the argonaute family. | 0.941 |
alg-2 | cgh-1 | T07D3.7a.1 | C07H6.5.1 | Protein argonaute; Belongs to the argonaute family. | ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.714 |
alg-2 | ergo-1 | T07D3.7a.1 | R09A1.1a.1 | Protein argonaute; Belongs to the argonaute family. | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] | 0.930 |
alg-2 | hbl-1 | T07D3.7a.1 | F13D11.2a.1 | Protein argonaute; Belongs to the argonaute family. | Hunchback-like protein; Required for the late stages of development. Plays a role in the developmental timing of postembryonic hypodermal seam cell fusion events and adult alae production. | 0.571 |
alg-2 | lin-14 | T07D3.7a.1 | T25C12.1a.1 | Protein argonaute; Belongs to the argonaute family. | Protein lin-14; Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of insulin/insulin- like growth factor gene ins-33. Isoform A may be involved in specifying L1 cell fates while isoform B1 and isoform B2 may specify L2 and later cell fates, creating a temporal switch. | 0.420 |
alg-2 | lin-28 | T07D3.7a.1 | F02E9.2a.1 | Protein argonaute; Belongs to the argonaute family. | Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family. | 0.455 |
alg-2 | lin-41 | T07D3.7a.1 | C12C8.3a.1 | Protein argonaute; Belongs to the argonaute family. | Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] | 0.970 |
car-1 | cgh-1 | Y18D10A.17.1 | C07H6.5.1 | Cytokinesis, Apoptosis, RNA-associated. | ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.999 |
car-1 | lin-41 | Y18D10A.17.1 | C12C8.3a.1 | Cytokinesis, Apoptosis, RNA-associated. | Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] | 0.921 |
car-1 | oma-1 | Y18D10A.17.1 | C09G9.6.1 | Cytokinesis, Apoptosis, RNA-associated. | CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] | 0.960 |
cgh-1 | alg-1 | C07H6.5.1 | F48F7.1b.1 | ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | Protein argonaute; Belongs to the argonaute family. | 0.864 |
cgh-1 | alg-2 | C07H6.5.1 | T07D3.7a.1 | ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | Protein argonaute; Belongs to the argonaute family. | 0.714 |