STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdfr-1Calcitonin receptor-like protein 1; G-protein coupled receptor for PDF neuropeptides. Activated by peptides PDF-1 and PDF-2 but to a lesser extent with isoform c. Isoforms a and b are thought to act through the G-alpha(s) type of G proteins to elevate cAMP levels whereas isoform c inhibits cAMP levels through the G-alpha(i/o) type of G proteins. Involved in locomotion; more specifically mate searching behavior independent of nutritional status. Might have a role in touch sensitivity. (546 aa)    
Predicted Functional Partners:
pdf-1
PDF (Arthropod Pigment Dispersing Factor) homolog.
   
  
 0.937
nlp-37
PDF (Arthropod Pigment Dispersing Factor) homolog.
   
  
 0.919
gsa-1
G protein, Subunit Alpha.
   
 
 0.771
C17H11.1
G_PROTEIN_RECEP_F1_2 domain-containing protein.
   
  
 0.671
lep-2
LEPtoderan male tail.
      
 0.660
npr-1
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
      
 0.623
T21H3.5
Uncharacterized protein.
      
 0.613
flp-21
FMRF-Like Peptide.
   
  
 0.597
npr-4
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.595
npr-11
Putative neuropeptide Y receptor 11; Could be a receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.573
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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