node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C16A11.4 | cbp-1 | C16A11.4a.1 | R10E11.1b.1 | SPK domain-containing protein. | Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. | 0.623 |
C16A11.4 | mrg-1 | C16A11.4a.1 | Y37D8A.9b.1 | SPK domain-containing protein. | MRG domain-containing protein. | 0.714 |
C16A11.4 | mys-1 | C16A11.4a.1 | VC5.4.1 | SPK domain-containing protein. | Histone acetyltransferase Tip60 homolog; Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates. Belongs to the MYST (SAS/MOZ) family. | 0.755 |
C16A11.4 | mys-2 | C16A11.4a.1 | K03D10.3a.1 | SPK domain-containing protein. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.770 |
C16A11.4 | mys-4 | C16A11.4a.1 | C34B7.4.1 | SPK domain-containing protein. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.767 |
C16A11.4 | rha-1 | C16A11.4a.1 | T07D4.3.1 | SPK domain-containing protein. | ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replicat [...] | 0.716 |
C16A11.4 | sdc-2 | C16A11.4a.1 | C35C5.1.2 | SPK domain-containing protein. | Sex determination and dosage compensation protein sdc-2; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto [...] | 0.610 |
C16A11.4 | ssl-1 | C16A11.4a.1 | Y111B2A.22a.1 | SPK domain-containing protein. | Helicase ssl-1; Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. | 0.856 |
C16A11.4 | sumv-2 | C16A11.4a.1 | F54D11.2.3 | SPK domain-containing protein. | Protein sumv-2; Influences the activity of genes involved in vulval development. | 0.569 |
C16A11.4 | wdr-5.1 | C16A11.4a.1 | C14B1.4.2 | SPK domain-containing protein. | WD repeat-containing protein wdr-5.1; Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3. Not required for demethylation of histone H3 'Lys-27'. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, pr [...] | 0.606 |
cbp-1 | C16A11.4 | R10E11.1b.1 | C16A11.4a.1 | Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. | SPK domain-containing protein. | 0.623 |
cbp-1 | mys-1 | R10E11.1b.1 | VC5.4.1 | Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. | Histone acetyltransferase Tip60 homolog; Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates. Belongs to the MYST (SAS/MOZ) family. | 0.661 |
cbp-1 | mys-2 | R10E11.1b.1 | K03D10.3a.1 | Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.522 |
cbp-1 | ssl-1 | R10E11.1b.1 | Y111B2A.22a.1 | Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. | Helicase ssl-1; Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. | 0.518 |
cbp-1 | wdr-5.1 | R10E11.1b.1 | C14B1.4.2 | Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. | WD repeat-containing protein wdr-5.1; Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3. Not required for demethylation of histone H3 'Lys-27'. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, pr [...] | 0.574 |
mrg-1 | C16A11.4 | Y37D8A.9b.1 | C16A11.4a.1 | MRG domain-containing protein. | SPK domain-containing protein. | 0.714 |
mrg-1 | mys-1 | Y37D8A.9b.1 | VC5.4.1 | MRG domain-containing protein. | Histone acetyltransferase Tip60 homolog; Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates. Belongs to the MYST (SAS/MOZ) family. | 0.860 |
mrg-1 | mys-2 | Y37D8A.9b.1 | K03D10.3a.1 | MRG domain-containing protein. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.971 |
mrg-1 | mys-4 | Y37D8A.9b.1 | C34B7.4.1 | MRG domain-containing protein. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.811 |
mrg-1 | rha-1 | Y37D8A.9b.1 | T07D4.3.1 | MRG domain-containing protein. | ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replicat [...] | 0.577 |