STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C16A3.4C2H2-type domain-containing protein. (375 aa)    
Predicted Functional Partners:
eif-6
Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing.
   
 0.985
T25G3.3
60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.
   
 
 0.982
C53H9.2
CP-type G domain-containing protein.
   
 
 0.970
W08E12.7
Peptidase_M24 domain-containing protein.
   
 
 0.964
rpl-29
60S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family.
   
 
 0.939
rpl-24.1
60S ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family.
   
 
 0.921
rpl-7
60S ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity).
   
 
 0.921
rpl-24.2
Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity).
   
 
 0.920
ngp-1
Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
   
 
 0.902
rpl-3
60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes; Belongs to the universal ribosomal protein uL3 family.
   
 
 0.901
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.