STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfx-1Transcriptional repressor NF-X1 homolog; May play a role in transcription regulation; Belongs to the NFX1 family. (1119 aa)    
Predicted Functional Partners:
rps-30
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
   0.864
nxt-1
NTF2-related export protein; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).
   
  
 0.841
fkb-2
Peptidylprolyl isomerase.
   
 
 0.827
fkb-8
Peptidylprolyl isomerase.
   
 
 0.827
rps-12
40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family.
    
 
 0.804
rpl-5
60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...]
    
 
 0.784
rps-13
40S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.
    
   0.759
rps-2
40S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.
    
   0.759
rps-15
40S ribosomal protein S15; Negatively regulates lifespan.
    
   0.759
rps-19
40S ribosomal protein S19; Belongs to the eukaryotic ribosomal protein eS19 family.
    
   0.759
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.