STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccdc-55Nuclear speckle splicing regulatory protein 1 homolog; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the NSRP1 family. (392 aa)    
Predicted Functional Partners:
rnf-121
RING finger protein 121; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the RNF121 family.
 
    
 0.974
cdc-5L
Cell Division Cycle related.
   
   0.926
rsr-1
PWI domain-containing protein.
   
 
 0.866
F37C12.1
Uncharacterized protein.
   
 
  0.864
sig-7
Peptidyl-prolyl cis-trans isomerase sig-7; Probable PPIase that accelerates the folding of proteins (By similarity). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Involved in RNA polymerase II (RNA pol II)-mediated transcription elongation, and in primary transcript splicing, including co-transcriptional trans- splicing, in association with the catalytic subunit of the RNA pol II complex ama-1. Also plays a role in the regulation of elongation-dependent phosphorylation of ama-1 to control transcription. Involved in the transc [...]
   
 0.855
cacn-1
Cactin; Plays a role during early embryonic development. Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis.
   
 
 0.846
smg-4
Smg4_UPF3 domain-containing protein.
   
 
  0.841
cyn-4
Peptidyl-prolyl cis-trans isomerase 4; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development.
   
  0.837
prp-17
WD_REPEATS_REGION domain-containing protein.
   
 
 0.835
cyn-10
Peptidyl-prolyl cis-trans isomerase 10; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
   
  0.830
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.