STRINGSTRING
rnf-5 protein (Caenorhabditis elegans) - STRING interaction network
"rnf-5" - Protein RNF-5 in Caenorhabditis elegans
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnf-5Protein RNF-5 (rnf-5) mRNA, complete cds (235 aa)    
Predicted Functional Partners:
sel-1
Suppressor/Enhancer of Lin-12; Protein SEL-1 (sel-1) mRNA, complete cds (685 aa)
     
 
  0.971
cup-2
Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner; Belongs to the derlin family (245 aa)
     
  0.968
R151.6
Derlin-2; May be required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Its precise function remains unclear, but its ability to complement der1 mutations in C.cerevisiae, suggests a similar function in the degradation of ER misfolded proteins (237 aa)
     
  0.955
cdc-48.2
Transitional endoplasmic reticulum ATPase homolog 2; Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it regulates expression of ER stress response genes (810 aa)
       
  0.946
cdc-48.1
Transitional endoplasmic reticulum ATPase homolog 1; Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it regulates expression of ER stress response genes (809 aa)
       
  0.945
ubq-1
Polyubiquitin-A; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-48-linked is involved in protein degradat [...] (838 aa)
       
  0.930
erl-1
ERLin (ER lipid raft associated protein) homolog; Protein ERL-1 (erl-1) mRNA, complete cds (312 aa)
     
  0.919
ubl-1
Ubiquitin-like protein 1-40S ribosomal protein S27a; Protein UBL-1, isoform a (ubl-1) mRNA, complete cds; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family (163 aa)
       
  0.918
rnf-121
Protein RNF-121 (rnf-121) mRNA, complete cds (409 aa)
     
   
  0.917
Y105E8A.2
Protein Y105E8A.2 (Y105E8A.2) mRNA, complete cds (535 aa)
     
 
  0.913
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
Server load: low (19%) [HD]