node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C16D2.1 | C49C3.10 | C16D2.1a.1 | C49C3.10a.1 | Uncharacterized protein. | Protein kinase domain-containing protein. | 0.562 |
C16D2.1 | alh-13 | C16D2.1a.1 | T22H6.2b.1 | Uncharacterized protein. | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.678 |
C16D2.1 | atf-7 | C16D2.1a.1 | C07G2.2c.2 | Uncharacterized protein. | BZIP domain-containing protein. | 0.745 |
C16D2.1 | cosa-1 | C16D2.1a.1 | Y71H2AM.7.1 | Uncharacterized protein. | CrossOver Site Associated. | 0.764 |
C16D2.1 | csn-5 | C16D2.1a.1 | B0547.1.1 | Uncharacterized protein. | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] | 0.615 |
C16D2.1 | fos-1 | C16D2.1a.1 | F29G9.4b.1 | Uncharacterized protein. | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | 0.897 |
C16D2.1 | gcn-2 | C16D2.1a.1 | Y81G3A.3b.1 | Uncharacterized protein. | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | 0.569 |
C16D2.1 | jnk-1 | C16D2.1a.1 | B0478.1a.1 | Uncharacterized protein. | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] | 0.562 |
C16D2.1 | taf-12 | C16D2.1a.1 | Y56A3A.4a.1 | Uncharacterized protein. | TFIID_20kDa domain-containing protein. | 0.652 |
C16D2.1 | wnk-1 | C16D2.1a.1 | C46C2.1n.2 | Uncharacterized protein. | Serine/threonine-protein kinase WNK; Serine/threonine-protein kinase which phosphorylates gck-3. Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3. Essential for larval development and the tubular formation of the excretory canals. | 0.764 |
C49C3.10 | C16D2.1 | C49C3.10a.1 | C16D2.1a.1 | Protein kinase domain-containing protein. | Uncharacterized protein. | 0.562 |
alh-13 | C16D2.1 | T22H6.2b.1 | C16D2.1a.1 | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Uncharacterized protein. | 0.678 |
alh-13 | gcn-2 | T22H6.2b.1 | Y81G3A.3b.1 | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | 0.717 |
atf-7 | C16D2.1 | C07G2.2c.2 | C16D2.1a.1 | BZIP domain-containing protein. | Uncharacterized protein. | 0.745 |
atf-7 | jnk-1 | C07G2.2c.2 | B0478.1a.1 | BZIP domain-containing protein. | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] | 0.678 |
cosa-1 | C16D2.1 | Y71H2AM.7.1 | C16D2.1a.1 | CrossOver Site Associated. | Uncharacterized protein. | 0.764 |
csn-5 | C16D2.1 | B0547.1.1 | C16D2.1a.1 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] | Uncharacterized protein. | 0.615 |
fos-1 | C16D2.1 | F29G9.4b.1 | C16D2.1a.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Uncharacterized protein. | 0.897 |
fos-1 | jnk-1 | F29G9.4b.1 | B0478.1a.1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] | 0.937 |
gcn-2 | C16D2.1 | Y81G3A.3b.1 | C16D2.1a.1 | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | Uncharacterized protein. | 0.569 |