STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hlh-25BHLH domain-containing protein. (268 aa)    
Predicted Functional Partners:
mxl-3
BHLH domain-containing protein.
      
 0.791
hlh-11
Helix-loop-helix protein 11.
      
 0.787
ref-1
REgulator of Fusion.
   
  
 0.705
hlh-10
BHLH domain-containing protein.
      
 0.699
math-1
MATH domain-containing protein.
      
 0.698
madf-9
MADF domain-containing protein.
      
 0.669
pals-30
Protein containing ALS2cr12 (ALS2CR12) signature.
      
 0.616
mxl-1
BHLH domain-containing protein.
      
 0.468
lin-22
BHLH domain-containing protein.
      
 0.461
hlh-26
Helix-loop-helix protein 26; Binds DNA via the E-box sequence 5'-CACGTG-3'. Binds DNA as a homodimer. Represses lag-2 transcription during embryogenesis via Notch signaling, in an unc-37-dependent manner. Also represses tbx-37 independent of Notch signaling.
   
 
0.429
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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