STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C18A3.3Probable rRNA-processing protein EBP2 homolog; Required for the processing of the 27S pre-rRNA. (340 aa)    
Predicted Functional Partners:
K12H4.3
Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.
   
 
 0.999
C43E11.9
60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.
   
 0.998
nst-1
Guanine nucleotide-binding protein-like 3 homolog; May play a role in regulating cellular proliferation in both germline and somatic tissues.
   
 0.998
lpd-7
Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.
   
 0.998
pro-2
Nucleolar complex protein 2 homolog; Required for normal somatic gonad development and for regulation of germline development and proliferation.
   
 0.997
rrp-1
Ribosomal RNA processing protein 1 homolog; May be involved in the generation of 28S rRNA. Belongs to the RRP1 family.
   
 0.997
H06I04.3
Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
   
 0.997
nifk-1
RRM domain-containing protein.
   
 
 0.997
Y54E10A.10
Ribosome production factor 2 homolog.
   
 
 0.997
nol-2
SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
   
 
 0.996
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.