STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C18B2.5Uncharacterized protein. (699 aa)    
Predicted Functional Partners:
F57F4.4
Uncharacterized protein.
   
  
 0.714
elt-7
Transcription factor elt-7; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Required for gut- specific differentiation, specifically acting with the GATA region- binding transcription factor elt-2 to control normal gene expression and promote normal formation of the intestine. May have a protective role in response to infection by Gram-negative bacteria such as P.aeruginosa.
   
  
 0.661
lys-8
LYSozyme.
   
   0.641
F49E2.2
SH3 domain-containing protein.
   
   0.576
hpo-34
Uncharacterized protein.
   
    0.553
ifb-2
Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413.
   
    0.541
unc-59
Septin-type G domain-containing protein.
     
  0.540
unc-61
Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
     
  0.540
gfi-1
GEI-4 (Four) Interacting protein.
   
  
 0.539
nep-17
NEPrilysin metallopeptidase family.
   
    0.538
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.