node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
act-5 | klc-1 | T25C8.2.2 | M7.2b.1 | ACTin. | TPR_REGION domain-containing protein. | 0.828 |
act-5 | klc-2 | T25C8.2.2 | C18C4.10b.1 | ACTin. | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | 0.830 |
act-5 | unc-104 | T25C8.2.2 | C52E12.2b.2 | ACTin. | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] | 0.412 |
act-5 | unc-116 | T25C8.2.2 | R05D3.7.1 | ACTin. | Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites. | 0.728 |
act-5 | unc-83 | T25C8.2.2 | W01A11.3a.1 | ACTin. | Nuclear migration protein unc-83; Cargo-specific adapter that is involved in nuclear migration during development and thereafter. Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it interacts with unc-84 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules. Within the complex, connects the nuclear envelope to the microtubule cytoskeleton through the kinesin-1 light chain protein klc-2 (most likely within the Kinesin 1 motor complex) to regulate nuclear migrations. Moreover [...] | 0.700 |
casy-1 | klc-1 | B0034.3a.1 | M7.2b.1 | CAlSYntenin/Alcadein homolog. | TPR_REGION domain-containing protein. | 0.871 |
casy-1 | klc-2 | B0034.3a.1 | C18C4.10b.1 | CAlSYntenin/Alcadein homolog. | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | 0.879 |
casy-1 | unc-116 | B0034.3a.1 | R05D3.7.1 | CAlSYntenin/Alcadein homolog. | Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites. | 0.411 |
jip-1 | klc-1 | F56D12.4a.1 | M7.2b.1 | PID domain-containing protein. | TPR_REGION domain-containing protein. | 0.971 |
jip-1 | klc-2 | F56D12.4a.1 | C18C4.10b.1 | PID domain-containing protein. | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | 0.983 |
jip-1 | unc-104 | F56D12.4a.1 | C52E12.2b.2 | PID domain-containing protein. | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] | 0.412 |
jip-1 | unc-116 | F56D12.4a.1 | R05D3.7.1 | PID domain-containing protein. | Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites. | 0.747 |
jip-1 | unc-16 | F56D12.4a.1 | ZK1098.10e.1 | PID domain-containing protein. | JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] | 0.850 |
kca-1 | klc-1 | C10H11.10.1 | M7.2b.1 | Kinesin 1 cargo adaptor alternative variant a. | TPR_REGION domain-containing protein. | 0.920 |
kca-1 | klc-2 | C10H11.10.1 | C18C4.10b.1 | Kinesin 1 cargo adaptor alternative variant a. | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | 0.868 |
kca-1 | klp-16 | C10H11.10.1 | C41G7.2.2 | Kinesin 1 cargo adaptor alternative variant a. | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.660 |
kca-1 | unc-104 | C10H11.10.1 | C52E12.2b.2 | Kinesin 1 cargo adaptor alternative variant a. | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] | 0.540 |
kca-1 | unc-116 | C10H11.10.1 | R05D3.7.1 | Kinesin 1 cargo adaptor alternative variant a. | Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites. | 0.927 |
klc-1 | act-5 | M7.2b.1 | T25C8.2.2 | TPR_REGION domain-containing protein. | ACTin. | 0.828 |
klc-1 | casy-1 | M7.2b.1 | B0034.3a.1 | TPR_REGION domain-containing protein. | CAlSYntenin/Alcadein homolog. | 0.871 |