STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glb-5GLOBIN domain-containing protein; Belongs to the globin family. (397 aa)    
Predicted Functional Partners:
npr-1
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.914
gcy-35
Soluble guanylate cyclase gcy-35; Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in [...]
      
 0.850
glb-26
Globin-like protein 26; Plays a role in electron transport. Utilizes the bis-histidyl hexacoordinated complex with iron to transfer electrons to cytochrome c and molecular oxygen. Plays a regulatory role in the periodicity of the defecation cycle under oxidative stress conditions. Not involved in imparting protection against general conditions of oxidative stress. May participate in redox reactions under anaerobic conditions.
      
 0.850
gcy-36
Soluble guanylate cyclase gcy-36; Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyper [...]
   
  
 0.814
glb-6
Globin-like protein 6; May play a role as physiological sensor for oxygen via redox signaling and/or electron transport.
   
  
 0.813
nath-10
RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
      
 0.811
glb-30
GLOBIN domain-containing protein; Belongs to the globin family.
      
 0.741
glb-1
Globin-like protein; May be a globin and may play a role in oxygen transport.
      
 0.741
glb-10
GLOBIN domain-containing protein; Belongs to the globin family.
      
 0.726
glb-9
Globin-like protein 9.
   
  
 0.702
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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