STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
inx-18Innexin; Structural component of the gap junctions. Belongs to the pannexin family. (436 aa)    
Predicted Functional Partners:
srg-13
Serpentine receptor class gamma-13.
      
 0.758
gpa-6
Guanine nucleotide-binding protein alpha-6 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.
      
 0.665
nlg-1
Neuroligin-1; Probable neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins (By similarity). Plays a role in the clustering of the GABA(A) receptor unc-49 at postsynaptic sites in neuromuscular junctions (NMJs) via the interaction with madd-4 and neurexin nrx-1 and is thereby required for normal GABAergic synaptic transmission. Belongs to the type-B carboxylesterase/lipase family.
   
  
 0.550
lgc-8
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
      
 0.530
dmsr-5
G_PROTEIN_RECEP_F1_2 domain-containing protein.
  
    0.474
C17F4.7
Uncharacterized protein.
      
 0.463
C24D10.5
Uncharacterized protein.
      
 0.463
M02G9.2
Uncharacterized protein.
      
 0.463
M02H5.8
Uncharacterized protein.
      
 0.463
Y45G12C.10
Uncharacterized protein.
      
 0.463
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.