STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dop-6G_PROTEIN_RECEP_F1_2 domain-containing protein. (682 aa)    
Predicted Functional Partners:
grk-2
G protein-coupled receptor kinase 2; Specifically phosphorylates the activated forms of G protein- coupled receptors (By similarity). Required in adult sensory neurons for chemotaxis. Plays a role in the ASH sensory neurons in the chemotaxis response to NaCl where it is likely to modulate the strength of the NaCl avoidance response which occurs at high NaCl concentrations. Required in the HSN motor neurons for normal egg laying by promoting phosphorylation of amine oxidase amx-2 which inhibits amx-2 activity, preventing metabolism of serotonin. Acts in head acetylcholine neurons to pos [...]
   
 0.814
tag-89
G_PROTEIN_RECEP_F1_2 domain-containing protein.
     
  0.800
egl-30
Heterotrimeric G protein alpha subunit.
   
 0.725
rgs-11
Regulator of G-protein signaling rgs-11.
     
 0.718
rgs-7
Regulator of G-protein signaling rgs-7; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunit egl-30 (G-alpha(q)), thereby driving it into its inactive GDP-bound form. May organize egl-30 into a stable multiprotein signaling complex, and thereby persistently inhibit egl-30 when triggered by calcium or phospholipids.
     
 0.667
rgs-2
Regulator of G-protein signaling rgs-2; Weakly inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, it acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior. Modulates chemotaxis responses by regulating negatively the sensitivity to quinine in ASH sensory neurons.
   
 
 0.647
kin-1
cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
   
 
 0.619
rgs-6
Regulator of G-protein signaling rgs-6.
   
 
 0.615
rgs-8.1
RGS domain-containing protein.
     
 0.610
npr-26
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
  
 
  0.607
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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