STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cst-2Protein kinase domain-containing protein. (421 aa)    
Predicted Functional Partners:
mob-1
Mps One Binder (Mats/MOB1) homolog.
   
 0.988
sav-1
SAlVador (Cell proliferation regulator) homolog.
   
 0.973
wts-1
Serine/threonine-protein kinase WARTS homolog; Phosphorylates yap-1 which may negatively regulate yap-1 nuclear localization. Plays an essential role in larval development. Regulates growth, the formation of gut granules, lifespan and cell and body sizes probably in synergy with the TGF-beta sma/mab pathway. Does not appear to regulate apoptosis and proliferation. In addition, may synergize with the TGF-beta daf-7 dauer pathway to regulate entry into the dauer stage. Maintains the cellular integrity of intestinal cells by regulating the localization of apical actin and junctional proteins.
  
 
0.968
cst-1
Serine/threonine-protein kinase cst-1 18kDa subunit; Serine/threonine-protein kinase which extends lifespan and delays tissue aging, probably by activating daf-16.
  
 
0.922
yap-1
Yes-associated protein homolog 1; Plays a role in thermal stress response and in aging.
    
 0.849
rsf-1
RASSF (Ras-association domain family) homolog.
   
 
 0.806
npr-25
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
      
 0.759
npr-7
G_PROTEIN_RECEP_F1_2 domain-containing protein.
      
 0.741
mob-2
Mps One Binder (Mats/MOB1) homolog.
   
 
 0.717
gar-1
Probable muscarinic acetylcholine receptor gar-1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
      
 0.693
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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