STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
qns-1Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (703 aa)    
Predicted Functional Partners:
nmat-2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate. Belongs to the eukaryotic NMN adenylyltransferase family.
  
 
 0.998
nmat-1
Nicotinamide-nucleotide adenylyltransferase.
  
 
 0.998
ndx-9
NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily.
  
 
 0.986
nprt-1
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family.
  
 
 0.983
sir-2.1
NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...]
  
 
 0.965
sir-2.3
NAD-dependent protein deacylase sir-2.3; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance. Might promote neuronal cell death under ischemic conditions and cell death in touch neurons induced by mec-4 channel hyperactivation, possibly downstream of the insulin-like receptor daf-2. Might attenuate the reactive oxygen species (ROS) scavenging system, that eliminates ROS in ischemic conditions, under dietary deprivation and when glycolysis is blocked ; Belongs to the sirtuin family. Clas [...]
    
 0.953
sir-2.4
NAD-dependent protein deacetylase sir-2.4; NAD-dependent protein deacetylase.
  
 
 0.948
sir-2.2
NAD-dependent protein deacylase sir-2.2; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance.
    
 0.946
nmrk-1
Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
  
  
 0.941
Y17G7B.10
NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
   
 
 0.929
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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