STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tbx-38Putative T-box protein 38. (303 aa)    
Predicted Functional Partners:
pop-1
Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors.
   
 
 0.729
hlh-14
BHLH domain-containing protein.
   
  
 0.701
pha-4
Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...]
    
 
 0.699
che-1
Transcription factor che-1; Transcription factor essential for the identity of ASE chemosensory neurons. Acts by activating expression of genes that are specific for ASE chemosensory neurons, such as seven-transmembrane receptors or guanylate cyclase. Also required to control the left/right asymmetry in ASE chemosensory neurons by regulating expression of genes such as cog-1 and ceh-36.
      
 0.583
ceh-43
Homeobox protein ceh-43; Required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability.
   
 
 0.567
ceh-51
Homeobox domain-containing protein.
   
 
 0.547
yap-1
Yes-associated protein homolog 1; Plays a role in thermal stress response and in aging.
    
  0.510
end-3
GATA-type domain-containing protein.
   
 
 0.505
end-1
GATA-type domain-containing protein.
   
 
 0.502
pcaf-1
P300/CBP Associated Factor homolog.
     
  0.499
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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