STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dao-5Nucleolar protein dao-5; Nucleolar protein which binds to RNA polymerase I and rDNA and is required for efficient RNA polymerase I-mediated rDNA transcription. Maintains the epigenetically active status of rDNA chromatin which facilitates rDNA transcription and sustains germline development, ensuring fertility. Plays a role in the modulation of nucleolus size. May play a role in the regulation of lifespan. Belongs to the NOLC1 family. (971 aa)    
Predicted Functional Partners:
nol-56
Nucleolar protein 56; Required for 60S ribosomal subunit synthesis. Belongs to the NOP5/NOP56 family.
   
 
 0.984
fib-1
rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (By similarity). Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl- L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein [...]
   
 
 0.975
K01G5.5
Putative H/ACA ribonucleoprotein complex subunit 4; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the pseudouridine synthase TruB family.
   
 
 0.974
nol-58
Nop domain-containing protein.
   
 
 0.973
F53F4.11
Uncharacterized protein.
   
 
 0.947
nol-6
Nucleolar protein 6.
   
  
 0.912
nol-2
SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
   
   0.907
pro-2
Nucleolar complex protein 2 homolog; Required for normal somatic gonad development and for regulation of germline development and proliferation.
   
  
 0.903
nst-1
Guanine nucleotide-binding protein-like 3 homolog; May play a role in regulating cellular proliferation in both germline and somatic tissues.
   
 
 0.887
F23B12.7
Uncharacterized protein F23B12.7; Belongs to the CBF/MAK21 family.
   
   0.871
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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