node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ajm-1 | dlg-1 | C25A11.4f.1 | C25F6.2a.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | 0.992 |
ajm-1 | erm-1 | C25A11.4f.1 | C01G8.5b.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | FERM domain-containing protein. | 0.810 |
ajm-1 | hmp-1 | C25A11.4f.1 | R13H4.4b.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Alpha-catenin-like protein hmp-1; Required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the vinculin/alpha-catenin family. | 0.813 |
ajm-1 | hmr-1 | C25A11.4f.1 | W02B9.1b.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Cadherin-related hmr-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton. Isoform b is involved in axonal guidance in a subset of motor neurons. | 0.769 |
ajm-1 | let-413 | C25A11.4f.1 | F26D11.11b.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...] | 0.866 |
ajm-1 | pkc-3 | C25A11.4f.1 | F09E5.1.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. | 0.723 |
ajm-1 | scm-1 | C25A11.4f.1 | M01D7.2a.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Secretory carrier-associated membrane protein. | 0.808 |
ajm-1 | unc-119 | C25A11.4f.1 | M142.1c.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. | 0.769 |
ajm-1 | vab-10 | C25A11.4f.1 | ZK1151.1l.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | GAR domain-containing protein. | 0.736 |
ajm-1 | vab-9 | C25A11.4f.1 | T22C8.8.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Cell junction protein VAB-9. | 0.799 |
dlg-1 | ajm-1 | C25F6.2a.1 | C25A11.4f.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | 0.992 |
dlg-1 | erm-1 | C25F6.2a.1 | C01G8.5b.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | FERM domain-containing protein. | 0.843 |
dlg-1 | hmp-1 | C25F6.2a.1 | R13H4.4b.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Alpha-catenin-like protein hmp-1; Required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the vinculin/alpha-catenin family. | 0.910 |
dlg-1 | hmr-1 | C25F6.2a.1 | W02B9.1b.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Cadherin-related hmr-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton. Isoform b is involved in axonal guidance in a subset of motor neurons. | 0.894 |
dlg-1 | let-413 | C25F6.2a.1 | F26D11.11b.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...] | 0.940 |
dlg-1 | pkc-3 | C25F6.2a.1 | F09E5.1.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. | 0.510 |
dlg-1 | vab-10 | C25F6.2a.1 | ZK1151.1l.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | GAR domain-containing protein. | 0.516 |
dlg-1 | vab-9 | C25F6.2a.1 | T22C8.8.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Cell junction protein VAB-9. | 0.625 |
erm-1 | ajm-1 | C01G8.5b.1 | C25A11.4f.1 | FERM domain-containing protein. | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | 0.810 |
erm-1 | dlg-1 | C01G8.5b.1 | C25F6.2a.1 | FERM domain-containing protein. | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | 0.843 |