STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-120Nuclear Hormone Receptor family. (477 aa)    
Predicted Functional Partners:
cyp-34A7
CYtochrome P450 family; Belongs to the cytochrome P450 family.
    
 
 0.814
cyp-35B3
CYtochrome P450 family; Belongs to the cytochrome P450 family.
    
 
 0.812
pqn-73
Prion-like-(Q/N-rich)-domain-bearing protein.
      
 0.808
nhr-162
Nuclear Hormone Receptor family.
   
  
 0.804
cyp-35D1
CYtochrome P450 family; Belongs to the cytochrome P450 family.
    
 
 0.705
ugt-25
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
      
 0.668
ugt-37
UDP-GlucuronosylTransferase.
   
  
 0.662
gei-8
Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
    
 0.577
cyp-35B1
CYtochrome P450 family; Belongs to the cytochrome P450 family.
    
 
 0.550
bar-1
Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...]
  
   0.546
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.