Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein (By similarity). Together with GTPase drn-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1.

Protein shank; Scaffold protein that most likely acts in the postsynaptic density (PSD) of excitatory synapses which orchestrates synapse formation and maintenance at neuromuscular junctions. Associates with and trafficks the L-type calcium channel egl-19 to the cell surface of body wall muscles to ensure the function of the calcium channel and therefore maintain the Ca(2+) current density. The maintenance of Ca(2+) also allows for the downstream regulation of Ca(2+)-induced expression of genes such as gem-4. Plays a role in the regulation of the defecation cycle, and this may be in as [...]

Rap guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle. Belongs to the RAPGEF2 family.

Ral GDS-Like.

Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...]

Uncharacterized protein.

Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...]

PDZ domain-containing protein.

Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Positively regulates lifespan upstream of mek-2 and mpk-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.