STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
swm-1Serine protease inhibitor swm-1; Serine protease inhibitor (Probable). Probably by inhibiting serine protease tyr-5 in males, prevents the maturation of spermatids into mature motile spermatozoa until their transfer into a hermaphrodite. Also required for efficient sperm transfer and thus for male fertility. (135 aa)    
Predicted Functional Partners:
try-5
Trypsin-like protease try-5; Serine protease which, in males, acts as a promoting signal during mating to activate sperm.
      
 0.912
spe-8
Spermatocyte protein spe-8; Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.
      
 0.854
spe-6
Serine/threonine-protein kinase spe-6; Serine/threonine-protein kinase which is involved in spermatogenesis. In spermatocytes, regulates meiosis and the localization and assembly of major sperm protein (MSP) into fibrous bodies. In addition, may suppress the initiation of spermiogenesis downstream of spe-8, spe-12, spe-27 and spe-29.
      
 0.850
snf-10
Transporter.
      
 0.816
spe-27
Spermatocyte protein spe-27; Required for spermiogenesis.
      
 0.808
spe-17
Spermatogenesis-defective protein spe-17.
      
 0.805
spe-29
Spermiogenesis protein SPE-29.
      
 0.741
F25E5.4
Peptidase S1 domain-containing protein.
   
  
 0.705
fer-1
Sperm vesicle fusion protein fer-1; Required for the fusion of the membranous organelles (MOs) with the plasma membrane, a process essential in spermiogenesis.
      
 0.698
spe-19
Uncharacterized protein.
      
 0.698
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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