STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-31Nuclear hormone receptor family member nhr-31; Orphan nuclear receptor. (583 aa)    
Predicted Functional Partners:
vha-20
Vacuolar H ATPase.
   
  
 0.853
mdt-11
Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
      
 0.798
best-3
Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family.
   
  
 0.675
srv-1
Serpentine receptor class V-1.
   
  
 0.674
B0334.4
PRELI/MSF1 domain-containing protein.
      
 0.667
C02B8.6
Uncharacterized RING finger protein C02B8.6.
      
 0.667
Y48A6B.8
Uncharacterized protein.
      
 0.667
sri-19
Serpentine Receptor, class I.
      
 0.667
mys-1
Histone acetyltransferase Tip60 homolog; Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates. Belongs to the MYST (SAS/MOZ) family.
    
 
 0.648
dcp-66
Deacetylase Complex Protein.
    
 
 0.603
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.