STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-258Nuclear Hormone Receptor family. (398 aa)    
Predicted Functional Partners:
gei-8
Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
    
 0.608
nhr-3
Nuclear hormone receptor family member nhr-3; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
  
 
 
0.577
npax-4
Paired domain-containing protein.
  
     0.528
npr-33
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
  
    0.519
nhr-38
Nuclear receptor domain-containing protein.
  
  
 
0.512
ets-7
ETS domain-containing protein.
  
 
   0.507
F19F10.1
ETS domain-containing protein.
  
 
   0.501
daf-14
MH2 domain-containing protein.
  
 
   0.493
nhr-25
Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop.
    
0.491
nhr-52
Nuclear hormone receptor family member nhr-52; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
  
    0.476
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.