node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C26B9.1 | aex-1 | C26B9.1a.2 | D2030.10a.2 | Uncharacterized protein. | C2 domain-containing protein aex-1; Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells. Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle exocytosis and thus regulate retrograde signaling at the neuromuscular junction (NMJ). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, plays a homeostatic role in the uptake of triglycerides. Regulat [...] | 0.816 |
C26B9.1 | alh-13 | C26B9.1a.2 | T22H6.2b.1 | Uncharacterized protein. | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.500 |
C26B9.1 | dld-1 | C26B9.1a.2 | LLC1.3a.1 | Uncharacterized protein. | Dihydrolipoyl dehydrogenase, mitochondrial. | 0.478 |
C26B9.1 | gsr-1 | C26B9.1a.2 | C46F11.2a.1 | Uncharacterized protein. | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr- 1, required for the reduction of disulfide groups in the cuticle during molting. | 0.472 |
C26B9.1 | syx-2 | C26B9.1a.2 | F48F7.2.2 | Uncharacterized protein. | Putative syntaxin-2; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. | 0.664 |
C26B9.1 | syx-3 | C26B9.1a.2 | F35C8.4.1 | Uncharacterized protein. | Putative syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). | 0.853 |
C26B9.1 | trxr-1 | C26B9.1a.2 | C06G3.7a.1 | Uncharacterized protein. | Thioredoxin reductase 1; Together with glutathione reductase gsr-1, required for the reduction of disulfide groups in the cuticle during molting. | 0.472 |
C26B9.1 | trxr-2 | C26B9.1a.2 | ZK637.10.1 | Uncharacterized protein. | Probable glutathione reductase 2; Maintains high levels of reduced glutathione in the cytosol. | 0.472 |
C26B9.1 | unc-64 | C26B9.1a.2 | F56A8.7a.2 | Uncharacterized protein. | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] | 0.465 |
aex-1 | C26B9.1 | D2030.10a.2 | C26B9.1a.2 | C2 domain-containing protein aex-1; Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells. Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle exocytosis and thus regulate retrograde signaling at the neuromuscular junction (NMJ). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, plays a homeostatic role in the uptake of triglycerides. Regulat [...] | Uncharacterized protein. | 0.816 |
aex-1 | syx-3 | D2030.10a.2 | F35C8.4.1 | C2 domain-containing protein aex-1; Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells. Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle exocytosis and thus regulate retrograde signaling at the neuromuscular junction (NMJ). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, plays a homeostatic role in the uptake of triglycerides. Regulat [...] | Putative syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). | 0.767 |
alh-13 | C26B9.1 | T22H6.2b.1 | C26B9.1a.2 | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Uncharacterized protein. | 0.500 |
alh-13 | dld-1 | T22H6.2b.1 | LLC1.3a.1 | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Dihydrolipoyl dehydrogenase, mitochondrial. | 0.702 |
alh-13 | gsr-1 | T22H6.2b.1 | C46F11.2a.1 | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr- 1, required for the reduction of disulfide groups in the cuticle during molting. | 0.702 |
alh-13 | trxr-1 | T22H6.2b.1 | C06G3.7a.1 | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Thioredoxin reductase 1; Together with glutathione reductase gsr-1, required for the reduction of disulfide groups in the cuticle during molting. | 0.702 |
alh-13 | trxr-2 | T22H6.2b.1 | ZK637.10.1 | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Probable glutathione reductase 2; Maintains high levels of reduced glutathione in the cytosol. | 0.703 |
dld-1 | C26B9.1 | LLC1.3a.1 | C26B9.1a.2 | Dihydrolipoyl dehydrogenase, mitochondrial. | Uncharacterized protein. | 0.478 |
dld-1 | alh-13 | LLC1.3a.1 | T22H6.2b.1 | Dihydrolipoyl dehydrogenase, mitochondrial. | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.702 |
gsr-1 | C26B9.1 | C46F11.2a.1 | C26B9.1a.2 | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr- 1, required for the reduction of disulfide groups in the cuticle during molting. | Uncharacterized protein. | 0.472 |
gsr-1 | alh-13 | C46F11.2a.1 | T22H6.2b.1 | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr- 1, required for the reduction of disulfide groups in the cuticle during molting. | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.702 |