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set-2 protein (Caenorhabditis elegans) - STRING interaction network
"set-2" - Histone-lysine N-methyltransferase set-2 in Caenorhabditis elegans
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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set-2Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates ’Lys-4’ of histone H3 at all developmental stages and in adult germ cells. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...] (1510 aa)    
Predicted Functional Partners:
nurf-1
Nucleosome-remodeling factor subunit NURF301-like; Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP- dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates; Belongs to the BPTF family (2197 aa)
     
 
  0.998
ash-2
Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at ’Lys-4’ of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] (572 aa)
     
 
  0.996
F21H12.1
Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at ’Lys-4’ of histone H3 (454 aa)
     
 
  0.992
rbr-2
Lysine-specific demethylase rbr-2; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. Required for normal longevity of the soma in a germline-dependent manner. Implicated in the epigenetic inheritance of lifespan over several generations. Involved in larval development and vulva formation (1477 aa)
     
 
  0.983
dpy-30
Dosage compensation protein dpy-30; Essential for dosage compensation. Required for the sex-specific association of the dosage compensation complex proteins dpy-27 and dpy-26 with the hermaphrodite X chromosomes. Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2. Required for the robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (123 aa)
       
 
  0.976
cfp-1
CFP1 (CpG-binding protein, CXXC Finger Protein 1) homolog; Protein F52B11.1, isoform a (508 aa)
     
 
  0.975
wdr-5.1
WD repeat-containing protein wdr-5.1; Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at ’Lys-4’. Required for di- and trimethylation, particularly for the trimethylation at ’Lys-4’ of histone H3. Not required for demethylation of histone H3 ’Lys-27’. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, pr [...] (376 aa)
     
 
  0.966
chd-1
Chromodomain and Helicase Domain protein; Protein CHD-1 (chd-1) mRNA, complete cds (1461 aa)
     
 
  0.964
utx-1
UTX (Ubiquitously transcribed TPR on X) homolog; Protein UTX-1 (utx-1) mRNA, complete cds (1168 aa)
     
 
  0.954
chd-7
Chromodomain and Helicase Domain protein; Protein CHD-7 (chd-7) mRNA, complete cds (2967 aa)
     
 
  0.947
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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