STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
let-391Uncharacterized protein. (453 aa)    
Predicted Functional Partners:
tag-267
Uncharacterized protein.
      
 0.808
let-381
Fork-head domain-containing protein.
    
 
 0.772
let-611
RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.721
let-630
Uncharacterized protein.
   
 
 0.716
coq-1
COenzyme Q (Ubiquinone) biosynthesis; Belongs to the FPP/GGPP synthase family.
   
  
 0.697
lim-7
LIM domain family.
   
 
 0.671
inx-12
Innexin-12; Structural component of the gap junctions (By similarity). Plays a role in oocyte directional transit in the spermatheca during ovulation by facilitating the directional propagation of the calcium signal in the spermatheca. Plays a role in male tail tip morphogenesis ; Belongs to the pannexin family.
      
 0.668
F27C1.6
Uncharacterized protein.
   
  
 0.661
mdt-18
Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
   
  
 0.625
let-383
Uncharacterized protein.
      
 0.616
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: medium (50%) [HD]