STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srj-4Serpentine Receptor, class J. (336 aa)    
Predicted Functional Partners:
daf-10
Intraflagellar transport protein 122 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a role in chemotaxis and sensory perception. Required for entry into and exit from the dauer larval stage and this may be mediated by daf-12, daf-16 and daf-41. Controls the behavioral response, namely the avoidance response, and pathogen-responsive gene expression in the response to pathogenic bacteria such as E.coli and P. aeruginosa.
   
 
 0.888
dyf-2
WD repeat-containing protein dyf-2; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Moves along the ciliary axoneme and is involved in the assembly, localization and the movement of other intraflagellar transport (IFT) proteins along the cilia axoneme. May also associate with the BBSome complex in order to mediate ciliary transport. Regulates cilia biogenesis, morphology and sensitivity to environmental cues.
    
 
 0.882
ifta-1
WD_REPEATS_REGION domain-containing protein.
    
 
 0.875
che-2
CHE-2 protein.
    
 
 0.573
elp-1
Echinoderm microtubule-associated protein-like elp-1; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family.
    
 
 0.497
C05D2.10
WD_REPEATS_REGION domain-containing protein.
    
 
 0.469
osm-1
Intraflagellar transport protein osm-1; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for the maintenance and formation of chemosensory cilia that detect chemosensory cues.
   
 
 0.455
ift-81
IFT81_CH domain-containing protein.
    
 
 0.447
unc-77
Uncharacterized protein.
    
 
 0.423
C27F2.1
WD Repeat protein.
    
 
 0.423
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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