STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spr-2Suppressor of presenilin-2; Potential corepressor protein, which may affect chromatin structure and/or transcription. May participate in the transcriptional repression of the presenilin protein hop-1. Belongs to the nucleosome assembly protein (NAP) family. (313 aa)    
Predicted Functional Partners:
htz-1
Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal [...]
   
 
 0.876
unc-85
Probable histone chaperone asf-1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
   
 
 0.741
nap-1
Nucleosome Assembly Protein; Belongs to the nucleosome assembly protein (NAP) family.
   
 
0.732
spr-3
Suppressor of presenilin protein 3; Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1.
   
 
 0.729
asfl-1
Probable histone chaperone asf-1-like protein; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
   
 
 0.723
spr-4
Suppressor of presenilin protein 4; Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1. Might play a role in the oxidative stress response.
   
 
 0.723
twk-1
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      
 0.663
nhx-4
Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
      
 0.660
rba-1
Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
   
 
 0.611
bub-3
Mitotic checkpoint protein bub-3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments of chromosomes. Necessary for expression and kinetochore localization of bub-1. Plays a role in synapsis checkpoint signaling inducing apoptosis in response to unsynapsed chromosomes and thus controlling chromosomal segregation during oocyte meiosis.
   
   0.601
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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