STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C27D6.11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa)    
Predicted Functional Partners:
msp-45
Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142.
   
 
 0.941
F58A6.9
Major Sperm Protein.
   
 
 0.941
srb-5
Serpentine receptor class beta-5; G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites.
    
 
 0.830
msp-40
Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
   
 
 0.818
C55C3.4
Tyrosine-protein kinase.
  
 
 0.722
srb-13
Serpentine receptor class beta-13; G-protein coupled receptor that antagonizes the negative effects of the gcy-35 oxygen sensor on spermatogenesis. This leads to the maintenance of mitochondrial function in developing spermatocytes and/or spermatids prior to testis maturation during the early larval stages. Regulates the navigational capacity of sperm during hyperoxic conditions ensuring the proper targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. May act in the same signaling pathway as the neuropeptide flp-21.
    
 
 0.722
srb-16
Serpentine receptor class beta-16; G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites ; Belongs to the nematode receptor-like protein srb family.
    
 
 0.722
C25A8.5
Tyrosine-protein kinase.
  
 
 0.720
cyc-2.2
Probable cytochrome c 2.2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
   
 
 0.704
spe-8
Spermatocyte protein spe-8; Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.
  
 
0.696
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.