STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spp-8SaPosin-like Protein family. (402 aa)    
Predicted Functional Partners:
clec-173
C-type lectin domain-containing protein.
   
  
 0.821
clec-63
C-type LECtin.
   
  
 0.812
clec-62
VWFA domain-containing protein.
   
  
 0.810
spp-16
Saposin B-type domain-containing protein.
   
  
 0.776
clec-150
C-type lectin domain-containing protein.
   
  
 0.747
nhr-193
Nuclear Hormone Receptor family.
   
  
 0.713
C29E4.10
Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family.
    
 
 0.709
clec-145
C-type lectin domain-containing protein.
   
  
 0.703
clec-210
C-type LECtin.
      
 0.698
asp-1
Aspartic protease 1; Aspartic protease, which is part of the necrosis cell death pathway. Promotes B.thuringiensis Cry6Aa stability by preventing its proteolysis by host gut proteases. Required for Cry6Aa-induced necrotic death of intestinal cells. Cry6Aa uptake into the host intestinal cells triggers an increase in intracellular Ca(2+) levels leading to lysosome rupture and to the subsequent release of asp-1 which leads to necrosis ; Belongs to the peptidase A1 family.
   
 0.697
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.