STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spp-10SaPosin-like Protein family. (429 aa)    
Predicted Functional Partners:
gba-4
Putative glucosylceramidase 4; Belongs to the glycosyl hydrolase 30 family.
   
 0.917
manf-1
Mesencephalic astrocyte-derived neurotrophic factor homolog; Inhibits endoplasmic reticulum (ER) stress response (By similarity). Retained in the ER under normal conditions and is up- regulated and secreted by the ER in response to ER stress and hypoxia (By similarity). Following secretion by the ER, directly binds to 3-O- sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress under ER stress conditions (By similarity). Has a neuroprotecti [...]
      
 0.836
lys-7
Lysozyme-like protein 7; Plays a role in resistance to Gram-positive bacteria B.thuringiensis and M.nematophilum and Gram-negative bacteria S.boydii or S.flexneri infection and to fungus C.neoformans infection. Plays a role in susceptibility to Gram-negative bacterium S.typhimurium infection. Belongs to the glycosyl hydrolase 25 family.
   
  
 0.815
spp-12
Saposin B-type domain-containing protein.
      
 0.808
spp-5
Saposin B-type domain-containing protein.
   
  
 0.769
spp-1
Saposin B-type domain-containing protein.
   
  
 0.760
chil-14
CHItinase-Like.
     
  0.750
C29E4.10
Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family.
    
 
 0.709
abf-2
Antibacterial factor-related peptide 2; Exhibits antimicrobial activity against the Gram-positive bacteria B.subtilis IFO 3134, K.varians MAFF 118076 and S.aureus ATCC 6538P, the Gram-negative bacteria A.tumefaciens MAFF 1001, B.bacteriovorus MAFF 106101 and K.pneumoniae MAFF 519002, and the yeasts C.krusei MAFF 114085, K.thermotolerans MAFF 113848 and T.delbrueckii MAFF 113811.
      
 0.700
spp-4
Saposin B-type domain-containing protein.
   
  
 0.696
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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