STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cka-1Choline Kinase A. (474 aa)    
Predicted Functional Partners:
daf-15
Raptor_N domain-containing protein.
   
 
 0.602
pkc-3
Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury.
   
   0.561
ckc-1
Choline Kinase C.
  
  
0.549
sinh-1
Stress-activated map kinase-interacting protein 1 homolog; May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).
    
 
 0.537
pcyt-2.1
CTP_transf_like domain-containing protein.
   
 
 0.509
pcyt-2.2
CTP_transf_like domain-containing protein.
   
 
 0.503
pcyt-1
Putative choline-phosphate cytidylyltransferase; Belongs to the cytidylyltransferase family.
     
 0.489
Y18H1A.11
CTP_transf_like domain-containing protein.
     
 0.489
ckb-3
Putative choline kinase B3; Belongs to the choline/ethanolamine kinase family.
  
  
 
0.469
ckb-1
Choline kinase B1; Belongs to the choline/ethanolamine kinase family.
  
  
 
0.459
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.