STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-138Nuclear Hormone Receptor family. (410 aa)    
Predicted Functional Partners:
ets-5
ETS domain-containing transcription factor ets-5; Transcription factor that plays a role in the differentiation and function of the CO(2)- and O(2)-sensing BAG neurons. The BAG neurons are required for the behavioral avoidance of environmental CO(2) and the sensing of decreased O(2) levels. Promotes the expression of genes that play a role in CO(2)- and O(2)-sensing and in egg-laying in the BAG neurons. Positively regulates the transcription of the receptor-type guanylate cyclase gcy-9, which is a critical component of the CO(2) transduction pathway, in the BAG neurons. May mediate tra [...]
  
 
 
 0.576
npr-26
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
  
   
 0.558
hlh-10
BHLH domain-containing protein.
  
   
 0.549
pax-2
Paired domain-containing protein.
  
   
 0.536
npax-4
Paired domain-containing protein.
  
     0.521
nhr-174
Nuclear hormone receptor family member nhr-174; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
  
     0.515
ets-7
ETS domain-containing protein.
  
 
   0.514
F19F10.1
ETS domain-containing protein.
  
 
   0.511
hlh-8
Twist-related protein; Acts as a transcriptional regulator. Involved in postembryonic mesodermal cell fate specification. Activates ceh-24 and egl-15 during mesodermal patterning.
  
     0.493
daf-14
MH2 domain-containing protein.
  
 
   0.491
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.