node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
asps-1 | npl-4.2 | B0024.10.1 | F59E12.5b.1 | TUG-UBL1 domain-containing protein. | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | 0.877 |
asps-1 | ubc-23 | B0024.10.1 | C28G1.1.1 | TUG-UBL1 domain-containing protein. | UAS domain-containing protein. | 0.840 |
asps-1 | ubxn-2 | B0024.10.1 | Y94H6A.9a.1 | TUG-UBL1 domain-containing protein. | UBX domain-containing protein 2; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. Probably in association with ATPase cdc-48.1 or/and cdc-48.2, regulates the centrosomal levels of kinase air-1 levels during mitotic progression by promoting air-1 removal from centrosomes in prophase. Also, regulates spindle orientation in the one-cell embryo by controlling [...] | 0.972 |
asps-1 | ubxn-6 | B0024.10.1 | H06H21.6.1 | TUG-UBL1 domain-containing protein. | UBX domain-containing protein 6; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. Involved in the lysosomal clearance of cellular material in diet restricted conditions. | 0.975 |
npl-4.2 | asps-1 | F59E12.5b.1 | B0024.10.1 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | TUG-UBL1 domain-containing protein. | 0.877 |
npl-4.2 | ubc-14 | F59E12.5b.1 | Y87G2A.9.1 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.675 |
npl-4.2 | ubc-15 | F59E12.5b.1 | Y110A2AR.2f.1 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.628 |
npl-4.2 | ubc-19 | F59E12.5b.1 | Y69H2.6.2 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.581 |
npl-4.2 | ubc-20 | F59E12.5b.1 | F40G9.3.1 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.474 |
npl-4.2 | ubc-21 | F59E12.5b.1 | C06E2.3.1 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | Probable ubiquitin-conjugating enzyme E2 21; Catalyzes the covalent attachment of ubiquitin to other proteins. | 0.498 |
npl-4.2 | ubc-23 | F59E12.5b.1 | C28G1.1.1 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | UAS domain-containing protein. | 0.810 |
npl-4.2 | ubc-8 | F59E12.5b.1 | Y94H6A.6.1 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.461 |
npl-4.2 | ubxn-2 | F59E12.5b.1 | Y94H6A.9a.1 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | UBX domain-containing protein 2; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. Probably in association with ATPase cdc-48.1 or/and cdc-48.2, regulates the centrosomal levels of kinase air-1 levels during mitotic progression by promoting air-1 removal from centrosomes in prophase. Also, regulates spindle orientation in the one-cell embryo by controlling [...] | 0.793 |
npl-4.2 | ubxn-6 | F59E12.5b.1 | H06H21.6.1 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | UBX domain-containing protein 6; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. Involved in the lysosomal clearance of cellular material in diet restricted conditions. | 0.734 |
ubc-14 | npl-4.2 | Y87G2A.9.1 | F59E12.5b.1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] | 0.675 |
ubc-14 | ubc-15 | Y87G2A.9.1 | Y110A2AR.2f.1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.670 |
ubc-14 | ubc-19 | Y87G2A.9.1 | Y69H2.6.2 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.808 |
ubc-14 | ubc-20 | Y87G2A.9.1 | F40G9.3.1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.625 |
ubc-14 | ubc-23 | Y87G2A.9.1 | C28G1.1.1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | UAS domain-containing protein. | 0.868 |
ubc-14 | ubc-8 | Y87G2A.9.1 | Y94H6A.6.1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.663 |