STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bcl-7BCL7-like protein; Required for the terminal differentiation of seam cells, and the differentiation of distal tip cells important for normal somatic gonad and germ cell development. Plays a role in the Wnt signaling pathway, regulating the expression of beta-catenin homologs wrm-1, bar- 1 and sys-1, and the localization of wrm-1 and the wnt signaling pathway component pop-1 during asymmetric cell division of seam cells and the Z-cell lineage of the somatic gonad, respectively. May have a pro-apoptotic role, possibly linked to the negative regulation of expression of anti-apoptotic fact [...] (146 aa)    
Predicted Functional Partners:
mxl-1
BHLH domain-containing protein.
   
  
 0.736
mxl-3
BHLH domain-containing protein.
      
 0.710
lsy-22
Uncharacterized protein.
      
 0.699
vps-37
VPS37 C-terminal domain-containing protein.
   
  
 0.652
mxl-2
BHLH domain-containing protein.
   
  
 0.651
snfc-5
SNF chromatin remodeling Complex component; Belongs to the SNF5 family.
   
 
 0.647
swsn-9
Bromo domain-containing protein.
   
 
 0.639
mml-1
Protein WBSCR14 homolog; Transcriptional repressor. Binds to the canonical and non- canonical E box sequences 5'-CACGTG-3' (By similarity).
      
 0.633
ZK973.9
Uncharacterized protein.
   
 
 0.631
M01E5.4
Uncharacterized protein.
   
 
 0.608
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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