node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C29E4.10 | R08F11.1 | C29E4.10.1 | R08F11.1a.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | 0.917 |
C29E4.10 | asah-1 | C29E4.10.1 | K11D2.2.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. | 0.974 |
C29E4.10 | asah-2 | C29E4.10.1 | F27E5.1.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Probable acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.980 |
C29E4.10 | cerk-1 | C29E4.10.1 | T10B11.2.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | 0.936 |
C29E4.10 | gba-1 | C29E4.10.1 | C33C12.3a.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Putative glucosylceramidase 1. | 0.971 |
C29E4.10 | gba-2 | C29E4.10.1 | C33C12.8.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Putative glucosylceramidase 2; Belongs to the glycosyl hydrolase 30 family. | 0.977 |
C29E4.10 | gba-3 | C29E4.10.1 | F11E6.1d.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Putative glucosylceramidase 3. | 0.971 |
C29E4.10 | gba-4 | C29E4.10.1 | Y4C6B.6.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Putative glucosylceramidase 4; Belongs to the glycosyl hydrolase 30 family. | 0.971 |
C29E4.10 | hyl-2 | C29E4.10.1 | K02G10.6.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.923 |
C29E4.10 | sms-1 | C29E4.10.1 | H21P03.3b.1 | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. | 0.933 |
R08F11.1 | C29E4.10 | R08F11.1a.1 | C29E4.10.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. | 0.917 |
R08F11.1 | asah-1 | R08F11.1a.1 | K11D2.2.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. | 0.921 |
R08F11.1 | asah-2 | R08F11.1a.1 | F27E5.1.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | Probable acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.923 |
R08F11.1 | cerk-1 | R08F11.1a.1 | T10B11.2.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | 0.933 |
R08F11.1 | gba-1 | R08F11.1a.1 | C33C12.3a.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | Putative glucosylceramidase 1. | 0.914 |
R08F11.1 | gba-2 | R08F11.1a.1 | C33C12.8.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | Putative glucosylceramidase 2; Belongs to the glycosyl hydrolase 30 family. | 0.913 |
R08F11.1 | gba-3 | R08F11.1a.1 | F11E6.1d.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | Putative glucosylceramidase 3. | 0.914 |
R08F11.1 | gba-4 | R08F11.1a.1 | Y4C6B.6.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | Putative glucosylceramidase 4; Belongs to the glycosyl hydrolase 30 family. | 0.912 |
R08F11.1 | hyl-2 | R08F11.1a.1 | K02G10.6.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.902 |
R08F11.1 | sms-1 | R08F11.1a.1 | H21P03.3b.1 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. | 0.910 |