STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
let-653Protein let-653; Required for epithelial tube development and shaping. Involved in the morphogenesis and function of the three unicellular tubes of the excretory system, the canal cell, the duct cell and the pore cell. Also plays a role in cuticle development, alae formation and shaping of the vulval lumen. Required for larval development. (812 aa)    
Predicted Functional Partners:
let-4
Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance.
   
  
 0.910
lpr-3
LiPocalin-Related protein.
   
  
 0.876
lpr-1
LiPocalin-Related protein.
   
  
 0.839
gly-11
Putative polypeptide N-acetylgalactosaminyltransferase 11; May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
   
  
 0.814
egg-6
Leucine-rich repeat-containing protein egg-6; Required for apical extracellular matrix organization and epithelial junction maintenance.
      
 0.809
sym-1
SYM-1 protein.
   
  
 0.775
rdy-2
Uncharacterized protein.
      
 0.758
noah-1
NOmpA Homolog (Drosophila nompA: no mechanoreceptor potential A).
   
  
 0.738
fbn-1
FiBrilliN homolog.
   
  
 0.721
gmd-2
GDP-mannose 4,6 dehydratase 2; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
   
  
 0.701
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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