STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
trpa-1Transient receptor potential cation channel subfamily A member 1 homolog; Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors. (1211 aa)    
Predicted Functional Partners:
ocr-2
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.883
osm-9
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.852
mec-10
Degenerin mec-10; Amiloride-sensitive sodium channel subunit required for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior.
   
  
 0.824
tpra-1
Transmembrane protein adipocyte-associated 1 homolog; Belongs to the UPF0359 family.
      
 0.794
gtl-1
LSDAT_euk domain-containing protein.
   
  
 0.782
mec-4
Degenerin mec-4; Probable sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior.
   
  
 0.777
ocr-3
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.766
degt-1
DEGenerin-related Touch-involved channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.763
pkc-2
Protein kinase C-like 2; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
   
 
 0.726
faah-1
Fatty acid amide hydrolase 1; Degrades bioactive fatty acid amides like palmitoyl ethanolamide (PEA), palmitoleoyl ethanolamide (POEA), oleoyl ethanolamide (OEA), linoleoyl ethanolamide (LOEA), arachidonoyl ethanolamide (anandamide, or AEA), and eicosapentaneoyl ethanolamide (EPEA), thereby serving to terminate the signaling functions of these molecules. EPEA promotes dauer formation and may constitute a signal of high nutrient availability. Breakdown of EPEA may promote lifespan extension when nutrient availability is high. Facilitates axon regeneration after injury by degradating inh [...]
   
 0.713
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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