node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C30G12.6 | aspm-1 | C30G12.6a.1 | C45G3.1.1 | Uncharacterized protein C30G12.6. | Calponin-homology (CH) domain-containing protein. | 0.923 |
C30G12.6 | bmk-1 | C30G12.6a.1 | F23B12.8b.1 | Uncharacterized protein C30G12.6. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.922 |
C30G12.6 | dpy-27 | C30G12.6a.1 | R13G10.1.1 | Uncharacterized protein C30G12.6. | Chromosome condensation protein dpy-27; Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase. Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome. Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on do [...] | 0.975 |
C30G12.6 | dpy-28 | C30G12.6a.1 | Y39A1B.3.1 | Uncharacterized protein C30G12.6. | Condensin complex subunit 1; Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex func [...] | 0.988 |
C30G12.6 | him-10 | C30G12.6a.1 | R12B2.4.1 | Uncharacterized protein C30G12.6. | Kinetochore protein Nuf2 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolymerizing microtubules. Belongs to the NUF2 family. | 0.904 |
C30G12.6 | klp-18 | C30G12.6a.1 | C06G3.2.1 | Uncharacterized protein C30G12.6. | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.874 |
C30G12.6 | mix-1 | C30G12.6a.1 | M106.1.1 | Uncharacterized protein C30G12.6. | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | 0.999 |
C30G12.6 | ndc-80 | C30G12.6a.1 | W01B6.9.1 | Uncharacterized protein C30G12.6. | Kinetochore protein ndc-80; Acts as a component of the essential kinetochore-associated ndc-80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. Plays a role in kinetochore assembly and recruits the checkpoint protein mdf-2 and the spindly-like protein spdl-1 to unattached kinetochores. Mediates the formation of end-on kinetochore-microtubule attachments through recruitment of spdl-1. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolym [...] | 0.905 |
C30G12.6 | pig-1 | C30G12.6a.1 | W03G1.6c.1 | Uncharacterized protein C30G12.6. | Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants. Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface. May act downstream of par-4/strd-1/mop-25 to regulate cell shedding. | 0.880 |
C30G12.6 | smc-4 | C30G12.6a.1 | F35G12.8.2 | Uncharacterized protein C30G12.6. | Structural maintenance of chromosomes protein 4; Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Also a central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation. Both the condensin complex I and II play a role in [...] | 0.976 |
aspm-1 | C30G12.6 | C45G3.1.1 | C30G12.6a.1 | Calponin-homology (CH) domain-containing protein. | Uncharacterized protein C30G12.6. | 0.923 |
aspm-1 | bmk-1 | C45G3.1.1 | F23B12.8b.1 | Calponin-homology (CH) domain-containing protein. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.988 |
aspm-1 | dpy-27 | C45G3.1.1 | R13G10.1.1 | Calponin-homology (CH) domain-containing protein. | Chromosome condensation protein dpy-27; Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase. Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome. Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on do [...] | 0.534 |
aspm-1 | dpy-28 | C45G3.1.1 | Y39A1B.3.1 | Calponin-homology (CH) domain-containing protein. | Condensin complex subunit 1; Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex func [...] | 0.579 |
aspm-1 | him-10 | C45G3.1.1 | R12B2.4.1 | Calponin-homology (CH) domain-containing protein. | Kinetochore protein Nuf2 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolymerizing microtubules. Belongs to the NUF2 family. | 0.962 |
aspm-1 | klp-18 | C45G3.1.1 | C06G3.2.1 | Calponin-homology (CH) domain-containing protein. | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.991 |
aspm-1 | mix-1 | C45G3.1.1 | M106.1.1 | Calponin-homology (CH) domain-containing protein. | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | 0.847 |
aspm-1 | ndc-80 | C45G3.1.1 | W01B6.9.1 | Calponin-homology (CH) domain-containing protein. | Kinetochore protein ndc-80; Acts as a component of the essential kinetochore-associated ndc-80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. Plays a role in kinetochore assembly and recruits the checkpoint protein mdf-2 and the spindly-like protein spdl-1 to unattached kinetochores. Mediates the formation of end-on kinetochore-microtubule attachments through recruitment of spdl-1. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolym [...] | 0.929 |
aspm-1 | pig-1 | C45G3.1.1 | W03G1.6c.1 | Calponin-homology (CH) domain-containing protein. | Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants. Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface. May act downstream of par-4/strd-1/mop-25 to regulate cell shedding. | 0.840 |
aspm-1 | smc-4 | C45G3.1.1 | F35G12.8.2 | Calponin-homology (CH) domain-containing protein. | Structural maintenance of chromosomes protein 4; Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Also a central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation. Both the condensin complex I and II play a role in [...] | 0.707 |