STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trh-1THR-like peptide hormone. (96 aa)    
Predicted Functional Partners:
flr-2
CTCK domain-containing protein.
      
 0.807
ceh-45
Homeobox domain-containing protein.
      
 0.691
nlp-13
Neuropeptide-Like Protein.
   
  
 0.688
flp-28
FMRF-Like Peptide.
   
  
 0.675
trhr-1
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
      
 0.660
vab-15
Homeobox protein vab-15; Probable transcription factor needed for the proper production of touch cell precursors. Essential for embryonic morphogenesis.
      
 0.660
nlp-8
Neuropeptide-Like Protein.
   
  
 0.581
nlp-3
Neuropeptide-Like Protein.
   
  
 0.555
ceh-34
Homeobox protein ceh-34; Acts as a transcription regulator. Binds to the cis-regulatory element of proapoptotic factor egl-1 gene and together with eya-1 activates egl-1 expression to promote motor neuron M4 sister cell apoptosis. Also promotes apoptosis of I1 pharyngeal neuron sister cell. Together with eya- 1, required to specify the coelomocyte fate in embryonic and postembryonic precursors. Belongs to the SIX/Sine oculis homeobox family.
      
 0.532
rig-6
Contactin rig-6; Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation. By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons. Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis. Plays a role in regulating male mating behavior.
      
 0.532
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.