STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C31H1.8Uncharacterized protein. (534 aa)    
Predicted Functional Partners:
perm-5
PERMeable eggshell.
   
  
 0.919
ify-1
Securin-like protein; Acts as a chaperone and as an inhibitor for separase sep-1. Plays an essential role in maintaining chromosome cohesion prior to meiotic and mitotic anaphase, in cytokinesis and in organizing the spindle and the centrosome. Ubiquitination-dependent degradation at the onset of anaphase is likely to activate sep-1 resulting in the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. Also required for cortical granule exocytosis.
   
  
 0.849
him-10
Kinetochore protein Nuf2 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolymerizing microtubules. Belongs to the NUF2 family.
   
  
 0.832
R148.7
Uncharacterized protein.
      
 0.818
ctn-1
Alpha-CaTuliN (Catenin/vinculin related).
      
 0.808
hcp-3
Histone H3-like centromeric protein hcp-3; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Might promote cleavage furrow stability during cytokinesis. Not required for chromosome segregation during meiosis.
   
  
 0.751
C27D9.1
Uncharacterized protein.
   
   0.649
hrde-1
Uncharacterized protein C16C10.3.
   
    0.592
rnp-8
RRM domain-containing protein.
   
    0.592
Y45G5AM.2
Uncharacterized protein; Belongs to the peptidase M24B family.
   
    0.574
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.