STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dpy-8Col_cuticle_N domain-containing protein. (452 aa)    
Predicted Functional Partners:
dpy-9
Col_cuticle_N domain-containing protein.
  
  
0.895
col-128
COLlagen.
  
  
0.881
T06G6.6
Uncharacterized protein.
   
    0.860
dpy-2
Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.
  
  
0.836
dpy-6
DumPY: shorter than wild-type.
   
  
 0.819
sqt-1
Cuticle collagen sqt-1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. This is a collagen critical for organismal morphogenesis. Mutations in sqt-1 can lengthen, shorten, or helically twist the entire animal.
  
  
0.738
qua-1
Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development.
   
  
 0.734
sqt-2
Col_cuticle_N domain-containing protein.
  
  
0.710
lon-3
Cuticle collagen lon-3; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape.
  
  
0.709
rol-6
Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis.
  
  
0.708
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (20%) [HD]