STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acr-19AcetylCholine Receptor. (560 aa)    
Predicted Functional Partners:
unc-50
Protein unc-50; Required for cell surface expression of acetylcholine receptors in body-wall muscles.
      
 0.671
ric-3
Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors; Belongs to the ric-3 family.
   
  
 0.670
lgc-38
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
  
  
 0.580
lgc-25
Neur_chan_LBD domain-containing protein.
  
 
0.579
lgc-26
Neur_chan_LBD domain-containing protein.
  
 
0.579
acc-1
Acetylcholine-gated chloride channel subunit acc-1; Acetylcholine-gated chloride channel subunit. Forms functional homopentameric (in vitro) and functional heteropentameric ion channels with acc-3 and acc-4 ion channel subunits. Currents in channels are triggered in response to acetylcholine, but not in response to GABA, glutamate, glycine, histamine or dopamine.
  
  
 0.572
acr-25
AcetylCholine Receptor.
  
0.572
acr-14
AcetylCholine Receptor.
  
 
0.549
acr-7
Acetylcholine receptor subunit alpha-type acr-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  
 
0.536
molo-1
Uncharacterized protein.
   
  
 0.526
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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