STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rilp-1RILP (Rab7-Interacting Lysosomal Protein) homolog. (419 aa)    
Predicted Functional Partners:
ppm-1.H
PPM-type phosphatase domain-containing protein.
      
 0.851
dyrb-1
Dynein light chain roadblock; Belongs to the GAMAD family.
      
 0.806
flcn-1
UDENN FLCN/SMCR8-type domain-containing protein.
      
 0.723
gpa-16
Guanine nucleotide-binding protein alpha-16 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In the 1-cell embryo, probably together with goa-1, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisons, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Belongs to the G-alpha family.
   
  
 0.619
rab-35
RAB family.
   
  
 0.597
rab-8
RAB family.
   
 
 0.560
rab-10
Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...]
   
 
 0.560
lin-5
Spindle apparatus protein lin-5; Essential component of the spindle apparatus required for spindle positioning and chromosome movement. Acts to recruit or anchor gpr-1/gpr-2 complex to the spindle and cortex. Also involved, directly or indirectly, in cytokinesis and in the coupling of DNA replication, centrosome duplication and mitotic division.
   
  
 0.478
arl-8
Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family.
   
 
 0.471
ehbp-1
EH (Eps-15-homology) domain Binding Protein family.
   
  
 0.444
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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