STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
set-4Histone-lysine N-methyltransferase Suv4-20; Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity). Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway. (288 aa)    
Predicted Functional Partners:
set-1
Histone-lysine N-methyltransferase set-1; Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched on hermaphrodite X chromosomes and during mitosis. Involved in dosage compensation by repression of X-linked gene expression in hermaphrodites. Plays a role in growth and body fat regulation downstream of the TOR complex 2 pathway. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.
   
  
 0.944
set-15
SET domain-containing protein.
   
  
 0.844
dpy-21
Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating the chromosome architecture. Promotes chromatin compaction by converting H4k20me2 to H4K20me1 leading to transcriptional repression. Required for X chromosome dosage compensation by enriching H4K20me1 on X chromosomes and thereby reducing X-linked gene transcription in hermaphrodites throughout development. X chromosome specificity is mediated by the recruitment through proteins of the condensin-like dosage compensation complex (DCC). Requ [...]
   
  
 0.839
jmjd-1.1
JmjC domain-containing protein.
   
  
 0.818
set-2
Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...]
   
  
 0.814
met-1
Histone-lysine N-methyltransferase.
   
  
 0.748
set-25
Histone-lysine N-methyltransferase set-25; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate. Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina. Required for small-RNA-induced H3K9 methylation. Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription- induced replication stress through methylation of H3K9.
   
  
 0.709
dpy-27
Chromosome condensation protein dpy-27; Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase. Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome. Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on do [...]
   
  
 0.703
cct-7
T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
      
 0.666
dpy-28
Condensin complex subunit 1; Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex func [...]
   
  
 0.661
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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