STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ric-19Resistance to inhibitors of cholinesterase protein 19; May be involved in a role in neurotransmitter secretion. (430 aa)    
Predicted Functional Partners:
cccp-1
CARD domain-containing protein.
   
  
 0.869
tbc-8
Rab-GAP TBC domain-containing protein.
   
 
 0.867
rund-1
RUN domain-containing protein.
   
 
 0.867
unc-108
Uncharacterized protein.
    
 
 0.842
F54C8.7
Uncharacterized protein F54C8.7.
      
 0.743
Y57G11C.22
Uncharacterized protein.
   
 
 0.710
nlp-21
Neuropeptide-Like Protein.
   
  
 0.662
C47D12.2
Uncharacterized protein.
      
 0.637
ida-1
Receptor-type tyrosine-protein phosphatase-like ida-1; Regulates dense-core vesicle (DCV) trafficking and/or secretion. Probably by controlling DCV trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Involved in locomotion by regulating acetylcholine release. Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior. Plays a role in preventing dauer formation. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
   
  
 0.619
egl-3
Neuroendocrine convertase 2; Serine endoprotease which cleaves preproteins at paired basic amino acids. Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. Probably by processing flp-1 and flp-18, modulates the neuronal excitation-inhibition balance and thus the level of activity of the locomotor circuit. Regulates sensitivity to mechanosensory stimuli. By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions. Probably by processing flp neuropeptides, regulates the turning step of male mating behavior. [...]
   
  
 0.581
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.