STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dod-24CUB_2 domain-containing protein. (361 aa)    
Predicted Functional Partners:
C17H12.8
CUB_2 domain-containing protein.
   
  
 0.805
irg-4
CUB_2 domain-containing protein.
   
  
 0.754
irg-5
CUB_2 domain-containing protein.
   
  
 0.715
T24B8.5
Uncharacterized protein.
   
  
 0.707
dod-3
Downstream Of DAF-16 (Regulated by DAF-16).
      
 0.690
dod-23
Downstream Of DAF-16 (Regulated by DAF-16).
      
 0.670
F56A4.2
C-type lectin domain-containing protein.
   
  
 0.666
daf-16
Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...]
      
 0.661
clec-67
C-type lectin domain-containing protein.
   
  
 0.646
clec-209
C-type LECtin.
   
  
 0.626
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.